منابع مشابه
Acetate Fuels the Cancer Engine
Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and histone modification.
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Cancer is a disease of the genome and the epigenome. Previous studies have shown that genomic changes such as mutations, copy number variation, and genomic rearrangements drive cancer evolution. In this issue of Cancer Cell, Landau and colleagues add epigenomic changes, specifically locally disordered DNA methylation, to cancer's evolutionary trajectory.
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Deep genomic sequencing technologies are beginning to resolve the underlying complexities of solid and hematologic cancers. Peter Nowell’s proposed model for cancer evolution suggesting that cancers evolve through branched evolutionary trajectories fuelled by genomic instability is now increasingly being accepted as a basis for therapeutic failure and the increasing mismatch between cost and cl...
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Effects of Social Support and Isolation Lutgendorf is also examining links between depression and social support or isolation and survival in ovarian cancer patients. She studied the presence of MMPs, vascular endothelial growth factor, interleukin 6, tumor norepinephrine, and NK cells. She found associations between these protumor substances and social isolation. Patients with higher levels of...
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To the Editors: The recent article reporting no association of consumption of animal foods with risk of ovarian cancer (1) was based on an incomplete study (2). Whereas ecologic studies can find animal products as an important risk factor for breast cancer (2, 3), a more recent ecologic study based on ovarian cancer mortality rates for European countries for 1989 to 1991 and dietary data for th...
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ژورنال
عنوان ژورنال: Cancer
سال: 2009
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.24125